Barangay San Francisco is also part of the South District Division of Barangays in Tarlac City. Barangay Atioc and Barangay Capehan bound it on the North, Barangay Dela Paz on the West, Barangay Sapang Tagalog on the East, Barangay San Carlos and Barangay Burot on the South.

It is approximately 7.8 kilometers away from city proper. It has a total land area of 285.40 hectares. The 165.00 hectares corresponds to an agricultural area and the remaining 120.4 hectares designate to a commercial area and residential.

It is also devided into seven blocks namely: Block 1, Block 2, and Block 3 to Block 7.

Barangay San Francisco classified as Rural Barangay, it has a total population of two thousand two hundred fifteen (2,215) as of 2005, and a household population of four hundred nineteen (419).

Barangay San Francisco was both agricultural and commercial barangay. One of their major sources of livelihood is farming. Almost 60% of the total populace in this barangay was farmers. They cultivate palay, corn, and vegetables. Other residents were employees, laborers, construction workers and so on. Some residents have their own business such as sari-sari stores and so on. Other business establishments situated here were gasoline station, burger machine, and many more.

Barangay San Francisco was formerly a sitio of Barangay Sapang Tagalog. According to their elders, the first settlers of this barangay came from its neighboring barangay which most of them are from “Panu”-the Western part of the barangay. It was in 1940s and 1950s when people started to settle here. Before, the place was a quiet and peaceful. The migrants carried their Patron Saint San Francisco. The reason why people migrated in this barangay is simply to escape unpleasant condition of their former place. And when this place was populated, they filed a petition for a separation of this Sitio from their Mother Barangay Sapang Tagalog. And approximately in the 1960s it was established as a new barangay in Tarlac City and was named after its Patron Saints St. Francis.

Lacsa, Martilino, and Bondoc Family were the pioneer who settled here.

Eighty percent of the total populations are Pampango, and the rest are Tagalog, Bisaya, Pangasinense, and Ilocano.

Barangay San Francisco celebrates their Feast Day every February 20-21 as barangay feast day and October as Patron Feast. Their Patron was Saint Francis of Assissi. Saint Francis of Assisi (September 26, 1181 – October 3, 1226) was a Roman Catholic friar and the founder of the Order of Friars Minor, more commonly known as the Franciscans. He is known as the patron saint of animals, birds, and the environment, and it is customary for Catholic churches to hold ceremonies honoring animals around his feast day of October 4.